Collective sperm movement in mammalian reproductive tracts

Hirashima, Tsuyoshi; Sound WP; Taichi Noda

doi:10.51094/jxiv.917

##article.authors##

Hirashima, Tsuyoshi National University of Singapore, Mechanobiology Institute https://orcid.org/0000-0001-7323-9627 https://researchmap.jp/tsuyoshi-hirashima
Sound WP National University of Singapore, Mechanobiology Institute
Taichi Noda Kumamoto University, Institute of Resource Development and Analysis https://researchmap.jp/taichi_noda

DOI:

https://doi.org/10.51094/jxiv.917

キーワード:

Collective sperm movement、 Imaging、 Mammalian reproductive tracts、 Mechanobiology、 Mechano-chemical feedback、 Sperm motility

抄録

Mammalian sperm cells travel from their origin in the male reproductive tract to fertilization in the female tract through a complex process driven by coordinated mechanical and biochemical mechanisms. Recent experimental and theoretical advances have illuminated the collective behaviors of sperm both in vivo and in vitro. However, our understanding of the underlying mechano-chemical processes remains incomplete. This review integrates current insights into sperm group movement, examining both immotile and motile states, which are essential for passive transport and active swimming through the reproductive tracts. We provide an overview of the current understanding of collective sperm movement, focusing on the experimental and theoretical mechanisms behind these behaviors. We also explore how sperm motility is regulated through the coordination of mechanical and chemical processes. Emerging evidence highlights the mechanosensitive properties of a sperm flagellum, suggesting that mechanical stimuli regulate flagellar beating at both individual and collective levels. This self-regulatory, mechano-chemical system reflects a broader principle observed in multicellular systems, offering a system-level insight into the regulation of motility and collective dynamics in biological systems.

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The authors declare no competing interests.

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