脳オルガノイドを用いた自閉スペクトラム症の病態メカニズム解明：環境要因の影響評価と課題
##article.authors##
- 中村, 賢佑 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
- 左中, 彩恵 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
- 樋口, 浩輝 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
- 久保, 明澄 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
- 神谷, 沙羅 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
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佐々木, 哲也
筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
https://orcid.org/0000-0002-7723-4417
https://researchmap.jp/tsasak
DOI:
https://doi.org/10.51094/jxiv.894キーワード:
自閉スペクトラム症、 脳オルガノイド、 環境要因、 in vitroモデル、 神経発達抄録
自閉スペクトラム症（ASD）は複雑な神経発達障害であり、その病態メカニズム解明が急務となっている。近年、ヒト幹細胞から作製される脳オルガノイド技術が、ASD研究に革新をもたらしている。この三次元培養モデルは、ASDの環境要因研究に特に有用である。薬剤曝露や感染などの環境因子がヒトの神経発達に与える影響を直接観察でき、長期的な影響評価も可能である。また、患者由来のiPS細胞を用いることで、個々の遺伝的背景を考慮した研究が実現する。これらの利点により、ASDの複雑な病因解明に新たな洞察をもたらしている。一方で、成熟度の限界や再現性の課題も存在する。倫理的配慮を重視しつつ、技術改良や他分野との融合により、これらの欠点克服が進められている。今後、この技術はASDの病態解明と新規治療法開発の加速に大きく貢献すると期待される。
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投稿日時: 2024-09-08 08:22:36 UTC
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中村, 賢佑
左中, 彩恵
樋口, 浩輝
久保, 明澄
神谷, 沙羅
佐々木, 哲也
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