Elucidating the Pathogenic Mechanisms of Autism Spectrum Disorder Using Brain Organoids: Assessment of Environmental Factors and Challenges
##article.authors##
- Kenyu Nakamura Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Sae Sanaka Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Koki Higuchi Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Asumi Kubo Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Sara Kamiya Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
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Tetsuya Sasaki
Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
https://orcid.org/0000-0002-7723-4417
https://researchmap.jp/tsasak
DOI:
https://doi.org/10.51094/jxiv.894Keywords:
Autism Spectrum Disorder, Brain Organoids, Environmental Factors, in vitro Models, NeurodevelopmentAbstract
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, and elucidating its pathogenic mechanisms is an urgent task. Recently, brain organoid technology derived from human stem cells has brought innovation to ASD research. This three-dimensional culture model is particularly useful for studying environmental factors in ASD. It allows direct observation of how environmental factors such as drug exposure and infections affect human neurodevelopment, and enables long-term impact assessment. Furthermore, using iPSCs derived from patients makes it possible to conduct research considering individual genetic backgrounds. These advantages provide new insights into the complex etiology of ASD. However, challenges such as limitations in maturity and reproducibility exist. While emphasizing ethical considerations, efforts are being made to overcome these drawbacks through technological improvements and integration with other fields. In the future, this technology is expected to significantly contribute to accelerating the elucidation of ASD pathology and the development of new therapeutic approaches.
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Submitted: 2024-09-08 08:22:36 UTC
Published: 2024-09-10 08:29:17 UTC
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Copyright (c) 2024
Kenyu Nakamura
Sae Sanaka
Koki Higuchi
Asumi Kubo
Sara Kamiya
Tetsuya Sasaki
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
