Potential Corneal Donation in Patients with Out-of-Hospital Cardiac Arrest: a Case-Control Study

Okazaki, Yuji; Noritomo Fujisaki; Hideto Fukui; Kyongko Huh; Takayuki Otani; Toshihisa Ichiba; Hiroshi Naito; Yuki Kataoka

doi:10.51094/jxiv.881

##article.authors##

Okazaki, Yuji Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Noritomo Fujisaki Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Hideto Fukui Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Kyongko Huh Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Takayuki Otani Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Toshihisa Ichiba Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Hiroshi Naito Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital
Yuki Kataoka Department of Internal Medicine, Kyoto Min-iren Asukai Hospital

DOI:

https://doi.org/10.51094/jxiv.881

キーワード:

Case-control study、 Corneal donation、 Emergency department、 Out-of-hospital cardiac arrest、 Potential donor

抄録

Aim: The shortage of corneal donations has been a longstanding problem in Japan. However, there are limited data on the settings in which corneal donations occur. The aim of this study was to determine the association between out-of-hospital cardiac arrest (OHCA) and corneal donation. We also investigated potential corneal donors across various death settings (OHCA, in-hospital cardiac arrest (IHCA) and home death).

Methods: We conducted a case-control study in Hiroshima Prefecture, Japan from 2015 to 2023. Cases included all corneal donors based on data provided by Hiroshima Eye Bank, while controls consisted of potential corneal donors in Hiroshima City Hiroshima Citizens Hospital. After matching cases with controls at a 1:5 ratio using age group, sex, and date of death, we employed unconditional logistic regression to analyze the association between OHCA and corneal donation.

Results: Among 4877 subjects, 190 were corneal donors and 3394 were potential corneal donors. Among corneal donors, 5.3% had OHCA, 26% had IHCA, and 29% died at home or in nursing homes. Of all subjects, 72% were potential corneal donors, with OHCA patients showing the highest proportion (75%). After adjusting matching factors, OHCA was positively associated with corneal donation (13% vs 15%; odds ratio: 2.2, 95% confidence interval: 1.3-3.5).

Conclusion: Individuals who experienced OHCA may be more likely than individuals in other settings of death to become corneal donors. Further research is needed to confirm the findings in this study and explore strategies to address the issue of Japan's corneal donation shortage.

利益相反に関する開示

The authors declare that they have no conflict of interest.

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引用文献

Yamada M, Mochizuki H. Current status and the future of Keratoplasty. IRYO. 2004; 58: 499-504.

Shinozaki N. Eye Donation and Overseas Cornea For a High Level of Transplant Cornea Supply. Rinsho ganka. 2018; 72: 1199-1204.

Gain P, Jullienne R, He Z, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016; 134: 167-73.

Steering Committee of the Istanbul Summit. Organ trafficking and transplant tourism and commercialism: the Declaration of Istanbul. The Lancet. 2008; 372: 5-6.

Okada Y, Nakagawa K, Tanaka H, et al. Overview and future prospects of out-of-hospital cardiac arrest registries in Japan. Resusc Plus. 2024; 17: 100578.

Hiroshima prefecture [homepage on the internet]. Population Migration Statistics Survey [Update March 2024; cited 30 August 2024] https://www.pref.hiroshima.lg.jp/site/toukei/jinkouidoutyosa.html#r5

Vandenbroucke JP, Von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. Epidemiology. 2007; 18: 805-35.

Hennessy S, Bilker WB, Berlin JA, Strom BL. Factors influencing the optimal control-to-case ratio in matched case-control studies. Am J Epidemiol. 1999; 149: 195-7.

Iwagami M, Shinozaki T. Introduction to Matching in Case-Control and Cohort Studies. Annals of Clinical Epidemiology. 2022; 4: 33-40.

Wittwer MR, Zeitz C, Beltrame JF, Arstall MA. Providing a simple and consistent solution for the definition of in- versus out-of-hospital cardiac arrest. Resuscitation. 2020; 156: 51-2.

Pampaka M, Hutcheson G, Williams J. Handling missing data: analysis of a challenging data set using multiple imputation. International Journal of Research & Method in Education. 2016; 39: 19-37.

White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011; 30: 377-99.

Organ Donation Taskforce. Organs for transplants: a report from the organ donation taskforce. London: Department of Health, 2008

Shaeri S, Considine J, Dainty KN, Olasveengen TM, Morrison LJ. Accuracy of etiological classification of out-of-hospital cardiac arrest: A scoping review. Resuscitation. 2024; 198: 110199.

Siminoff LA, Gordon N, Hewlett J, Arnold RM. Factors influencing families' consent for donation of solid organs for transplantation. JAMA. 2001; 286: 71-7.

Matsuyama T, Ohta B, Kiyohara K, Kitamura T. Cardiopulmonary resuscitation duration and favorable neurological outcome after out-of-hospital cardiac arrest: a nationwide multicenter observational study in Japan (the JAAM-OHCA registry). Crit Care. 2022; 26: 120.

Johnson D, Dutch M, Knott J. Estimation of the potential eye and tissue donor pool in an Australian emergency department. Emerg Med Australas. 2016; 28: 300–6.

Long J, Walsh D, Ritchie DA, Russell F. Corneal donation in the accident and emergency department: observational study. BMJ. 2000; 321: 1263-4.

Chopra GK, De Vincentis F, Kaufman D, Collie D. Effective corneal retrieval in a general hospital. The Royal Melbourne Hospital Eye Bank. Aust N Z J Ophthalmol. 1993; 21: 251-5.

Sasaki H, Nakamura H, Ono H, et al. Routine Referral by Urologists Increase Opportunities for Corneal Donation. Transplant Proc. 2018; 50: 2986-91.