Potential Corneal Donation in Patients with Out-of-Hospital Cardiac Arrest: a Case-Control Study
DOI:
https://doi.org/10.51094/jxiv.881Keywords:
Case-control study, Corneal donation, Emergency department, Out-of-hospital cardiac arrest, Potential donorAbstract
Aim: The shortage of corneal donations has been a longstanding problem in Japan. However, there are limited data on the settings in which corneal donations occur. The aim of this study was to determine the association between out-of-hospital cardiac arrest (OHCA) and corneal donation. We also investigated potential corneal donors across various death settings (OHCA, in-hospital cardiac arrest (IHCA) and home death).
Methods: We conducted a case-control study in Hiroshima Prefecture, Japan from 2015 to 2023. Cases included all corneal donors based on data provided by Hiroshima Eye Bank, while controls consisted of potential corneal donors in Hiroshima City Hiroshima Citizens Hospital. After matching cases with controls at a 1:5 ratio using age group, sex, and date of death, we employed unconditional logistic regression to analyze the association between OHCA and corneal donation.
Results: Among 4877 subjects, 190 were corneal donors and 3394 were potential corneal donors. Among corneal donors, 5.3% had OHCA, 26% had IHCA, and 29% died at home or in nursing homes. Of all subjects, 72% were potential corneal donors, with OHCA patients showing the highest proportion (75%). After adjusting matching factors, OHCA was positively associated with corneal donation (13% vs 15%; odds ratio: 2.2, 95% confidence interval: 1.3-3.5).
Conclusion: Individuals who experienced OHCA may be more likely than individuals in other settings of death to become corneal donors. Further research is needed to confirm the findings in this study and explore strategies to address the issue of Japan's corneal donation shortage.
Conflicts of Interest Disclosure
The authors declare that they have no conflict of interest.Downloads *Displays the aggregated results up to the previous day.
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Submitted: 2024-09-04 11:04:40 UTC
Published: 2024-09-06 09:48:46 UTC
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Copyright (c) 2024
Yuji Okazaki
Noritomo Fujisaki
Hideto Fukui
Kyongko Huh
Takayuki Otani
Toshihisa Ichiba
Hiroshi Naito
Yuki Kataoka
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