Pyrroloquinoline Quinone In Reducing Body Fat Function

The evidence from Obese Mice, Daphnia magna and Adipocytes studies

Abstract

Obesity is a significant public health issue and requires an effective countermeasure. Supplementation with functional food ingredient pyrroloquinoline quinone disodium salt (PQQ) has shown to improve brain function. Our study revealed PQQ function of reducing body fat. In obese mouse experiment, we found that PQQ supplementation reduced body fat of high-fat fed mice, especially the visceral fat. Moreover, PQQ supplementation prevented muscle loss due to the obesity. In a model experiment of daphnia, the effect of PQQ was confirmed to be equal to 30% calorie restriction. Additionally, experiments using adipocytes revealed that PQQ reduced the lipids in cell and increased the quantity of mitochondria. After investigating the mechanism, it is revealed that PQQ could inhibit the fatty acids production and suppress fat accumulation by improving fat metabolism via mitochondria biogenesis. We expect that PQQ could contribute to improve people's health as diet supplement.