プレプリント / バージョン1

自閉スペクトラム症の薬物療法:エビデンスと臨床判断の実際

##article.authors##

  • 佐々木, 哲也 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室 https://orcid.org/0000-0002-7723-4417 https://researchmap.jp/tsasak
  • 左中, 彩恵 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
  • 神谷, 沙羅 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室

DOI:

https://doi.org/10.51094/jxiv.980

キーワード:

診断上の課題、 代償性適応、 併存疾患、 非定型抗精神病薬、 有害事象の管理

抄録

自閉スペクトラム症(ASD)の診断において、知的障害を伴わないケースでは、高い知的能力による代償的な適応により、表面的には定型発達との区別が困難となることがある。また、発達段階による症状表現の変化や、成人期における長年の代償的適応により、基本的な特性が把握しにくい場合も多い。特に女性では、社会性の模倣や対人関係における代償的な方略の獲得により、典型的なASD特性が見えにくい傾向がある。さらに、不安障害や気分障害などの併存症が前景に立つ場合、基礎にあるASD特性の評価が困難となる。診断には複数の場面での行動観察と詳細な発達歴の聴取を丁寧に行うことが求められる。また、発達段階や性差による症状表現の違い、併存症の影響を考慮した包括的な評価が不可欠である。特に、代償的な適応を示す高機能例では、環境変化によって顕在化する困難さにも注目する必要がある。これらの多面的な評価により、より適切な診断と支援につながることが期待される。

利益相反に関する開示

著者らは競合する利害関係がないことを宣言する。

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著者の経歴

左中, 彩恵、筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室

筑波大学 医学群医学類

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投稿日時: 2024-11-30 13:44:34 UTC

公開日時: 2024-12-05 00:32:50 UTC
研究分野
生物学・生命科学・基礎医学