IL-17 signaling and neuroimmunology: Psoriasis to Autism Spectrum Disorder
##article.authors##
- 久保, 明澄 筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
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佐々木, 哲也
筑波大学 医学医療系 生命医科学域 解剖学・神経科学研究室
https://orcid.org/0000-0002-7723-4417
https://researchmap.jp/tsasak
DOI:
https://doi.org/10.51094/jxiv.869キーワード:
自閉スペクトラム症、 ドラッグリポジショニング、 IL-17/IL-17R阻害剤、 神経免疫学抄録
The IL-17 pathway is involved in diverse diseases, including psoriasis and autism spectrum disorder (ASD). IL-17 inhibitors have shown high efficacy in the treatment of psoriasis, and their indications are expanding to other autoimmune diseases; in ASD, it has been suggested that maternal IL-17 may affect fetal brain development, and existing psoriasis drugs may be applied to ASD interventions. In this paper, we discuss whether IL-17 inhibitors used for psoriasis treatment can be indicated for the prevention and treatment of autism. Further elucidation of the interaction between the immune system and the nervous system is expected to lead to the development of new therapeutic strategies.
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投稿日時: 2024-08-30 18:08:12 UTC
公開日時: 2024-09-05 08:38:37 UTC
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久保, 明澄
佐々木, 哲也
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