このプレプリントは論文として出版されています
DOI: https://doi.org/10.1093/pnasnexus/pgad207
プレプリント / バージョン1

Acoustic Needles: 3D Microfluidics using Focused Ultrasound passing through Hydrophobic Meshes

##article.authors##

  • Koroyasu, Yusuke Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Nguyen, Thanh-Vinh Sensing System Research Center, National Institute of Advanced Industrial Science and Technology (AIST)
  • Sasaguri, Shun School of Informatics, College of Media Arts, Science and Technology, University of Tsukuba
  • Marzo, Asier Computer Science, Public University of Navarre
  • Ezcurdia, Iñigo Computer Science, Public University of Navarre
  • Nagata, Yuuya Institute for Chemical Reaction Design and Discovery, Hokkaido University
  • Hoshi, Takayuki Pixie Dust Technologies, Inc.
  • Ochiai, Yoichi Faculty of Library, Information and Media Science, University of Tsukuba
  • Fushimi, Tatsuki Faculty of Library, Information and Media Science, University of Tsukuba https://orcid.org/0000-0003-3944-0014

DOI:

https://doi.org/10.51094/jxiv.166

キーワード:

Microfluidics、 Acoustic Radiation Force、 Hydrophobic、 Automation

抄録

Current experiments in chemistry, biology, medicine, and engineering require the manipulation of multiple chemicals, samples, and specimens on a large scale. Therefore, automation techniques for manipulating microliter droplets are essential to improve the throughput, reproducibility, and sustainability of experiments. Digital microfluidic methods, such as EWOD (electrowetting-on-dielectric), electrostatics, and acoustophoretic platforms, offer excellent maneuverability and fast control for droplets. However, they are limited in terms of three-dimensional (3D) manipulation and droplet size. Here, we propose an acoustic needles platform, a 3D digital microfluidics system based on focused ultrasound waves (3D-MFUS) that pass through a hydrophobic mesh with droplets resting on it. A focused beam (acoustic needle), generated dynamically by a phased array, creates a stable trap through the mesh and attracts droplets to its focus. This needle can be steered to translate droplets on the surface; droplets can be manipulated simultaneously by generating multiple foci. Moreover, a liquid droplet can be detached from the surface and propelled into mid-air for up to 10.9 cm. This height is 27 and 2 times greater than that observed in the state-of-the-art methods in EWOD and photovoltaics, respectively. Droplets can be merged or split by pushing them against a hydrophobic knife. Additionally, both solid particles and liquid droplets can be manipulated using the same system. This platform would allow scientists and engineers to manipulate liquid droplets in a 3D circuit; moreover, it paves the way for developments in micro-robotics, additive manufacturing, and laboratory automation research.

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引用文献

R. B. Fair. Digital microfluidics: is a true lab-on-a-chip possible? Microfluidics and Nanofluidics, 3(3):245–281, apr 2007.

Sidra Waheed, Joan M. Cabot, Niall P. Macdonald, Trevor Lewis, Rosanne M. Guijt, Brett Paull, and Michael C. Breadmore. 3D printed microfluidic devices: Enablers and barriers. Lab on a Chip, 16(11):1993–2013, 2016.

Yi Zhang and Nam Trung Nguyen. Magnetic digital microfluidics- a review. Lab on a Chip, 17(6):994–1008, 2017.

Udayan Umapathi, Patrick Shin, Ken Nakagaki, Daniel Leithinger, and Hiroshi Ishii. Programmable Droplets for Interaction. In Extended Abstracts of the 2018 CHI Conference on Human Factors in Computing Systems, pages 1–1, New York, NY, USA, apr 2018. ACM.

Thomas Franke, Adam R Abate, David A Weitz, and Achim Wixforth. Surface acoustic wave (saw) directed droplet flow in microfluidics for pdms devices. Lab on a Chip, 9(18):2625–2627, 2009.

Xin Tang, Pingan Zhu, Ye Tian, Xuechang Zhou, Tiantian Kong, and Liqiu Wang. Mechano-regulated surface for manipulating liquid droplets. Nature Communications, 8:1–10, 2017.

Yuankai Jin, Wanghuai Xu, Huanhuan Zhang, Ruirui Li, Jing Sun, Siyan Yang, Minjie Liu, Haiyang Mao, and Zuankai Wang. Electrostatic tweezer for droplet manipulation. Proceedings of the National Academy of Sciences, 119(2), 2022.

Chao Yang, Yongfeng Ning, Xiaoyong Ku, Guisheng Zhuang, and Gang Li. Automatic magnetic manipulation of droplets on an open surface using a superhydrophobic electromagnet needle. Sensors and Actuators, B: Chemical, 257:409–418, 2018.

Qiangqiang Sun, Dehui Wang, Yanan Li, Jiahui Zhang, Shuji Ye, Jiaxi Cui, Longquan Chen, Zuankai Wang, Hans Jürgen Butt, Doris Vollmer, and Xu Deng. Surface charge printing for programmed droplet transport. Nature Materials, 18(9):936–941, 2019.

Sung Kwon Cho, Hyejin Moon, and Chang-Jin Kim. Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits. Journal of Microelectromechanical Systems, 12(1):70–80, feb 2003.

Jeong Byung Chae, Seung Jun Lee, Jinseung Yang, and Sang Kug Chung. 3D electrowetting-on-dielectric actuation. Sensors and Actuators, A: Physical, 234:331–338, 2015.

Yuhang Mi, Xiaohu Liu, Zuoxuan Gao, Mengtong Wang, Lihong Shi, Xiong Zhang, Kaifang Gao, Euphrem Rwagasore Mugisha, and Wenbo Yan. 3D Photovoltaic Router of Water Microdroplets Aiming at Free-Space Microfluidic Transportation. ACS Applied Materials & Interfaces, 13(37):45018–45032, sep 2021.

Seung Jun Lee, Sanghyun Lee, and Kwan Hyoung Kang. Droplet jumping by electrowetting and its application to the three-dimensional digital microfluidics. Applied Physics Letters, 100(8):081604, 2012.

Seung Jun Lee, Jiwoo Hong, Kwan Hyoung Kang, In Seok Kang, and Sang Joon Lee. Electrowetting-induced droplet detachment from hydrophobic surfaces. Langmuir, 30(7):1805–1811, 2014.

Zhantao Wang, Dirk van den Ende, Arjen Pit, Rudy Lagraauw, Daniël Wijnperlé, and Frieder Mugele. Jumping drops on hydrophobic surfaces, controlling energy transfer by timed electric actuation. Soft Matter, 13(28):48564863, 2017.

Koji Takeda, Akira Nakajima, Kazuhito Hashimoto, and Toshiya Watanabe. Jump of water droplet from a super-hydrophobic film by vertical electric field. Surface science, 519(1-2):L589–L592, 2002.

B. Traipattanakul, C.Y. Tso, and Christopher Y.H. Chao. Study of jumping water droplets on superhydrophobic surfaces with electric fields. International Journal of Heat and Mass Transfer, 115:672–681, dec 2017.

Weishan Yan, Chaopeng Zhao, Wenyao Luo, Wangyang Zhang, Xi Li, and Duo Liu. Optically Guided Pyroelectric Manipulation of Water Droplet on a Superhydrophobic Surface. ACS Applied Materials and Interfaces, 13(19):23181–23190, 2021.

Ning Li, Lei Wu, Cunlong Yu, Haoyu Dai, Ting Wang, Zhichao Dong, and Lei Jiang. Ballistic Jumping Drops on Superhydrophobic Surfaces via Electrostatic Manipulation. Advanced Materials, 30(8):1703838, feb 2018.

Marco A. B. Andrade, Nicolás Pérez, and Julio C. Adamowski. Review of Progress in Acoustic Levitation. Brazilian Journal of Physics, 48(2):190–213, apr 2018.

D. Foresti, M. Nabavi, M. Klingauf, A. Ferrari, and D. Poulikakos. Acoustophoretic contactless transport and handling of matter in air. Proceedings of the National Academy of Sciences, 110(31):12549–12554, 2013.

Marco A. B. Andrade, Thales S. A. Camargo, and Asier Marzo. Automatic contactless injection, transportation, merging, and ejection of droplets with a multifocal point acoustic levitator. Review of Scientific Instruments, 89(12):125105, 2018.

Ayumu Watanabe, Koji Hasegawa, and Yutaka Abe. Contactless Fluid Manipulation in Air: Droplet Coalescence and Active Mixing by Acoustic Levitation. Scientific Reports, 8(1):10221, dec 2018.

Stephen J Brotton and Ralf I Kaiser. Controlled chemistry via contactless manipulation and merging of droplets in an acoustic levitator. Analytical Chemistry, 92(12):8371–8377, 2020.

Teruhiko Matsubara and Kenjiro Takemura. Containerless Bioorganic Reactions in a Floating Droplet by Levitation Technique Using an Ultrasonic Wave. Advanced Science, 8(3):1–5, 2021.

R. R. Whymark. Acoustic field positioning for containerless processing. Ultrasonics, 13(6):251–261, nov 1975.

Asier Marzo, Sue Ann Seah, Bruce W. Drinkwater, Deepak Ranjan Sahoo, Benjamin Long, and Sriram Subramanian. Holographic acoustic elements for manipulation of levitated objects. Nature Communications, 6(May):8661, oct 2015.

Henrik Bruus. Acoustofluidics 7: The acoustic radiation force on small particles. Lab on a Chip, 12(6):1014–1021, 2012.

Asier Marzo, Adrian Barnes, and Bruce W. Drinkwater. TinyLev: A multi-emitter single-axis acoustic levitator. Review of Scientific Instruments, 88(8):085105, aug 2017.

Kai Melde, Andrew G. Mark, Tian Qiu, and Peer Fischer. Holograms for acoustics. Nature, 537(7621):518–522, 2016.

Luke Cox, Kai Melde, Anthony Croxford, Peer Fischer, and Bruce W Drinkwater. Acoustic Hologram Enhanced Phased Arrays for Ultrasonic Particle Manipulation. Phys. Rev. Applied, 12(6):64055, dec 2019.

Tatsuki Fushimi, Asier Marzo, Bruce W Drinkwater, and Thomas L Hill. Acoustophoretic volumetric displays using a fast-moving levitated particle. Applied Physics Letters, 115(6):064101, 2019.

Benjamin Long, Sue Ann Seah, Tom Carter, and Sriram Subramanian. Rendering volumetric haptic shapes in mid-air using ultrasound. ACM Transactions on Graphics (TOG), 33(6):1–10, 2014.

Asier Marzo and Bruce W. Drinkwater. Holographic acoustic tweezers. Proceedings of the National Academy of Sciences, 116(1):84–89, 2018.

Tatsuki Fushimi, Kenta Yamamoto, and Yoichi Ochiai. Acoustic hologram optimisation using automatic differentiation. Scientific Reports, 11(1):12678, jun 2021.

Thanh-Vinh Nguyen, Hironao Okada, Yuki Okamoto, Yusuke Takei, Atsushi Takei, and Masaaki Ichiki. Direct measurement of impacting force between a droplet and a superhydrophobic blade. In 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS), pages 771–774, 2021.

Shuaijun Pan, Arun K Kota, Joseph M Mabry, and Anish Tuteja. Superomniphobic surfaces for effective chemical shielding. Journal of the American Chemical Society, 135(2):578–581, 2013.

Rafael Morales, Iñigo Ezcurdia, Josu Irisarri, Marco AB Andrade, and Asier Marzo. Generating airborne ultrasonic amplitude patterns using an open hardware phased array. Applied Sciences, 11(7):2981, 2021.

L. P. Gor’kov. On the Forces Acting on a Small Particle in an Acoustical Field in an Ideal Fluid. Soviet Physics Doklady, 6:773, 1962.

Carl Andersson and Jens Ahrens. Acoustic levitation from superposition of spherical harmonics expansions of elementary sources: Analysis of dependency on wavenumber and order. In 2019 IEEE International Ultrasonics Symposium (IUS), pages 920–923. IEEE, 2019.

Carl Andersson. Acoustic levitation of multi-wavelength spherical bodies using transducer arrays of nonspecialized geometries. The Journal of the Acoustical Society of America, 151(5):2999–3006, may 2022.

Sebastian Zehnter, Marco A. B. Andrade, and Christoph Ament. Acoustic levitation of a Mie sphere using a 2D transducer array. Journal of Applied Physics, 129(13):134901, apr 2021.

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投稿日時: 2022-09-13 00:24:22 UTC

公開日時: 2022-09-15 08:53:23 UTC
研究分野
一般工学・総合工学