Interleukin-17A (IL-17A): Molecular Characteristics and Its Physiological and Pathological Significance - From Molecular Structure to Clinical Applications
##article.authors##
- Chikako Sakamoto Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Sae Sanaka Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Sara Kamiya Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Asumi Kubo Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Kenyu Nakamura Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
- Koki Higuchi Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
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Tetsuya Sasaki
Laboratory of Anatomy and Neuroscience, Department of Biomedical Sciences, Institute of Medicine, University of Tsukuba
https://orcid.org/0000-0002-7723-4417
https://researchmap.jp/tsasak
DOI:
https://doi.org/10.51094/jxiv.965Keywords:
cytokine receptors, IL-17A signaling, psychiatric disorders, Th17 cells, transcriptional regulationAbstract
Interleukin-17A (IL-17A) is a proinflammatory cytokine that plays a crucial role in immune responses and tissue homeostasis. The expression of IL-17A is strictly regulated by transcription factors including RORγt and is mainly produced by Th17 cells, γδT cells, and innate lymphoid cells. IL-17A signals through a heterodimeric receptor complex consisting of IL-17RA and IL-17RC, leading to the activation of NF-κB and MAPK pathways. Recent studies have highlighted its functions in the central nervous system, with reported associations with multiple sclerosis and autism spectrum disorder. Furthermore, the development of IL-17A inhibitors has progressed significantly, showing high therapeutic efficacy particularly in autoimmune diseases. This review provides an overview of current knowledge regarding IL-17A, from its molecular characteristics to clinical applications.
Conflicts of Interest Disclosure
The authors declare that they have no competing interests.Downloads *Displays the aggregated results up to the previous day.
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Submitted: 2024-11-17 13:32:30 UTC
Published: 2024-11-20 01:01:04 UTC
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Copyright (c) 2024
Chikako Sakamoto
Sae Sanaka
Sara Kamiya
Asumi Kubo
Kenyu Nakamura
Koki Higuchi
Tetsuya Sasaki
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
