Comparison of Liberality Between Melanocyte Stem Cells and Differentiated Cells in Mice

Norichika Ogata

doi:10.51094/jxiv.909

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Norichika Ogata Nihon BioData Corp., Osaka University, Graduate School of Engineering, Department of Biotechnology, Manufacturing Technology Association of Biologics https://orcid.org/0000-0002-6856-6655 https://researchmap.jp/n0rr

DOI:

https://doi.org/10.51094/jxiv.909

Keywords:

Liberality, Transcriptome, Melanocyte, differentiation, dedifferentiation, single-cell RNA-seq

Abstract

Liberality refers to the degree of cellular dedifferentiation/differentiation, quantified through the estimation of information entropy from numeric transcriptome data and Lempel-Ziv complexity from transcriptome sequence data. In a previous study, single-cell RNA-seq data for melanocyte stem cells (McSCs) and melanocytes were obtained. Based on the definition of liberality, McSCs are expected to exhibit higher liberality than differentiated melanocytes. In this study, we estimated and compared the liberality between these two cell types.

Conflicts of Interest Disclosure

The authors declare no conflicts of interest associated with this manuscript.

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Author Biography

Norichika Ogata, Nihon BioData Corp., Osaka University, Graduate School of Engineering, Department of Biotechnology, Manufacturing Technology Association of Biologics

2023.06-(Today) Visiting Professor, Osaka University
2022.03-2023.03 Visiting Associate Professor, Tokyo University of Agriculture and Technology
2018.08-2023.06 CEO, Medicale Meccanica Inc.
2015.07-2020.03 General Manager, Chitose Bio Evolution Pte. Ltd.
2014.07-(Today) Adviser of Genomics, Manufacturing Technology Association of Biologics
2013.04-2015.06 Researcher, Neo-Morgan Laboratory Inc.
2013.02-(Today) CEO, Nihon BioData Corporation.
2010.04-2013.03 Doctor course student, United Graduate School of Agricultural Science Tokyo University of Agriculture and Technology
2008.04-2010.03 Master course student, Graduate School of Agriculture, Tokyo University of Agriculture and Technology
2004.04-2008.03 Undergraduate student, Faculty of Agriculture, Tokyo University of Agriculture and Technology

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