Aging, disease and transcriptomic liberality derived from human RNA-seq data
DOI:
https://doi.org/10.51094/jxiv.1758Keywords:
LiberalityAbstract
Human tissues progressively lose their function during aging. In the context of cellular differentiation and dedifferentiation, this process can be quantified as decrease and increase in liberality, defined as transcriptome diversity. In this study, we collected over 5,000 human transcriptome datasets and measured their liberality. We found a positive correlation between aging and liberality, as well as between disease status and liberality.
Conflicts of Interest Disclosure
The authors declare no conflicts of interest associated with this manuscript.Downloads *Displays the aggregated results up to the previous day.
References
Goldstein, S. (1990). Replicative senescence: the human fibroblast comes of age. Science (New York, N.Y.), 249(4973), 1129–1133. https://doi.org/10.1126/science.2204114
Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., Liu, B., Ai, J., Liu, F., Zhao, L., Zhang, J., Zhang, H., Sun, S., Huang, H., Zhang, Y., ... Liu, G.-H. (2024). Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell, 187(24), 7025–7044.e34. https://doi.org/10.1016/j.cell.2024.10.019
Ogata, N., Kozaki, T., Yokoyama, T., Hata, T., & Iwabuchi, K. (2015). Comparison between the amount of environmental change and the amount of transcriptome change. PloS One, 10(12), e0144822. https://doi.org/10.1371/journal.pone.0144822
Ogata, N., Yokoyama, T., & Iwabuchi, K. (2012). Transcriptome responses of insect fat body cells to tissue culture environment. PloS One, 7(4), e34940. https://doi.org/10.1371/journal.pone.0034940
R Core Team. (2024). R: A Language and Environment for Statistical Computing. https://www.R-project.org/
Shokhirev, M. N., & Johnson, A. A. (2021). Modeling the human aging transcriptome across tissues, health status, and sex. Aging Cell, 20(1), e13280. https://doi.org/10.1111/acel.13280
Downloads
Posted
Submitted: 2025-10-17 12:02:59 UTC
Published: 2025-10-24 01:30:43 UTC
License
Copyright (c) 2025
Norichika OGATA
This work is licensed under a Creative Commons Attribution 4.0 International License.
