Sensitivity Improvement of a silicon waveguide Mach-Zehnder interferometer sensor decorated with olfactory receptors
##article.authors##
- Hibiki Watanabe Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology
- Masahiko Hasumi Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology
- Yutaka Kuwamura Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
- Yosuke Fukutani Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
-
Hiromasa Shimizu
Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology
https://orcid.org/0000-0002-0627-8025
https://researchmap.jp/read0061106
DOI:
https://doi.org/10.51094/jxiv.1441Keywords:
Olfactory sensor, Si photonics, Olfactory receptor, Refractive index sensorAbstract
We characterized the response of the olfactory receptor (OR) OR51E2 to the target molecule sodium acetate using silicon Mach–Zehnder interferometer (MZI) sensors. Successful immobilization of the ORs on the Si surface was confirmed. The sensor exhibited reversible responses, with a sensitivity enhancement of 3.1-fold compared to a reference MZI sensor without ORs at a concentration of 1×10⁻³ mol/L. A substantial local refractive index change, estimated to be as high as 3.1×10⁻³ RIU, was derived from the experimental signals, demonstrating the potential of olfactory sensing based on silicon photonic technologies.
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Submitted: 2025-08-19 03:01:29 UTC
Published: 2025-08-25 08:14:24 UTC
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Hibiki Watanabe
Masahiko Hasumi
Yutaka Kuwamura
Yosuke Fukutani
Hiromasa Shimizu
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