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Association analysis between type 2 diabetes and the gut microbiota: a community-based cross-sectional study in Japan

##article.authors##

  • Koji Nagashima Department of Reseach & Development, TechnoSuruga Laboratory Co., Ltd.
  • Takayoshi Hisada Department of Reseach & Development, TechnoSuruga Laboratory Co., Ltd.
  • Jun Mochizuki Department of Research & Development, TechnoSuruga Laboratory Co., Ltd.
  • Tatsuya Mikami Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University
  • Yoshinori Tamada Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University
  • Shigeyuki Nakaji Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University

DOI:

https://doi.org/10.51094/jxiv.105

Keywords:

gut microbiota, type 2 diabetes, Lactobacillales, community-based cross-sectional study

Abstract

There are a few studies on the association between type 2 diabetes (T2D) and the gut microbiota but no community-based cross-sectional study. In the Iwaki Health Promotion Project (Hirosaki, Japan), we surveyed medical information and lifestyle and analyzed the gut microbiota using the terminal restriction fragment length polymorphism technique or next-generation sequencing. Based on these data, multivariable logistic regression analysis was performed with or without T2D as the dependent variable. Consequently, it was suggested that the Lactobacillales population in the gut microbiota was positively associated with T2D, consistent with the results of case-control studies.

Conflicts of Interest Disclosure

The authors declare no competing interests.

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Posted


Submitted: 2022-06-27 01:54:04 UTC

Published: 2022-06-28 09:35:04 UTC — Updated on 2023-08-14 06:19:38 UTC

Versions

Reason(s) for revision

Some sentences (lines 142-158) were added . Refference (20) was added. The Word "healed" in line 55 of text and footnote of Table 1was revised to "ameliorated". A supplement file was added.
Section
Biology, Life Sciences & Basic Medicine