Data for Brain Reference Architecture of SK25LHbDepressionModel

Seii Ko; Tawatsuji, Yoshimasa; Tatsunori Matsui

doi:10.51094/jxiv.1978

##article.authors##

Seii Ko School of Human Sciences, Waseda University
Tawatsuji, Yoshimasa Graduate School of Engineering, The University of Tokyo
Tatsunori Matsui Faculty of Human Sciences, Waseda University

DOI:

https://doi.org/10.51094/jxiv.1978

キーワード:

Brain Reference Architecture、 Lateral Habenula、 Major Depression Disorder、 Astrocyte

抄録

This dataset offers structural information (Brain Information Flow - BIF) about brain areas linked to Major Depressive Disorder (MDD), specifically focusing on the lateral habenula (LHN). Drawing from studies on stress circuits and neuron-glia interactions , the data defines several components: prelimbic cortex layer 6 neurons (PL.L6), LHN glutamatergic neurons ( LHN), locus coeruleus neurons ( LC), and LHN astrocytes (LHN astrocyte). It outlines connections within the PL.L6 → LHN → LC → LHN astrocyte → LHN circuit. Presented in the brain reference architecture (BRA) format, this dataset provides a framework for models looking into LHN circuit issues and their possible connection to depression symptoms.

利益相反に関する開示

The authors have no competing interests to declare.

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