Data for Brain Reference Architecture of SK25LHbDepressionModel
DOI:
https://doi.org/10.51094/jxiv.1978Keywords:
Brain Reference Architecture, Lateral Habenula, Major Depression Disorder, AstrocyteAbstract
This dataset offers structural information (Brain Information Flow - BIF) about brain areas linked to Major Depressive Disorder (MDD), specifically focusing on the lateral habenula (LHN). Drawing from studies on stress circuits and neuron-glia interactions , the data defines several components: prelimbic cortex layer 6 neurons (PL.L6), LHN glutamatergic neurons ( LHN), locus coeruleus neurons ( LC), and LHN astrocytes (LHN astrocyte). It outlines connections within the PL.L6 → LHN → LC → LHN astrocyte → LHN circuit. Presented in the brain reference architecture (BRA) format, this dataset provides a framework for models looking into LHN circuit issues and their possible connection to depression symptoms.
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The authors have no competing interests to declare.Downloads *Displays the aggregated results up to the previous day.
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Submitted: 2025-11-19 02:18:26 UTC
Published: 2025-11-28 08:54:36 UTC
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Copyright (c) 2025
Seii Ko
Yoshimasa Tawatsuji
Tatsunori Matsui
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
