Aging, disease and transcriptomic liberality derived from human RNA-seq data

Norichika OGATA

doi:10.51094/jxiv.1758

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Norichika OGATA Nihon BioData Corp. https://orcid.org/0000-0002-6856-6655

DOI:

https://doi.org/10.51094/jxiv.1758

キーワード:

Liberality

抄録

Human tissues progressively lose their function during aging. In the context of cellular differentiation and dedifferentiation, this process can be quantified as decrease and increase in liberality, defined as transcriptome diversity. In this study, we collected over 5,000 human transcriptome datasets and measured their liberality. We found a positive correlation between aging and liberality, as well as between disease status and liberality.

利益相反に関する開示

The authors declare no conflicts of interest associated with this manuscript.

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