Sensitivity Improvement of a silicon waveguide Mach-Zehnder interferometer sensor decorated with olfactory receptors

Hibiki Watanabe; Masahiko Hasumi; Yutaka Kuwamura; Yosuke Fukutani; Shimizu, Hiromasa

doi:10.51094/jxiv.1441

##article.authors##

Hibiki Watanabe Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology
Masahiko Hasumi Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology
Yutaka Kuwamura Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Yosuke Fukutani Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
Shimizu, Hiromasa Department of Applied Physics and Chemical Engineering, Tokyo University of Agriculture and Technology https://orcid.org/0000-0002-0627-8025 https://researchmap.jp/read0061106

DOI:

https://doi.org/10.51094/jxiv.1441

キーワード:

Olfactory sensor、 Si photonics、 Olfactory receptor、 Refractive index sensor

抄録

We characterized the response of the olfactory receptor (OR) OR51E2 to the target molecule sodium acetate using silicon Mach–Zehnder interferometer (MZI) sensors. Successful immobilization of the ORs on the Si surface was confirmed. The sensor exhibited reversible responses, with a sensitivity enhancement of 3.1-fold compared to a reference MZI sensor without ORs at a concentration of 1×10⁻³ mol/L. A substantial local refractive index change, estimated to be as high as 3.1×10⁻³ RIU, was derived from the experimental signals, demonstrating the potential of olfactory sensing based on silicon photonic technologies.

利益相反に関する開示

The authors declare that there are no conflicts of interest associated with this manuscript.

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