Comparative anatomy of respiratory bronchioles and lobular structures in mammals

Yumi Umeda; Takeshi Izawa; Kei Kazama; Sachiko Arai; Junichi Kamiie; Shinichiro Nakamura; Kazuki Hano; Masaki Takasu; Akihiko Hirata; Susanne Rittinghausen; Shotaro Yamano

doi:10.51094/jxiv.854

##article.authors##

Yumi Umeda National Institute of Occupational Safety and Health, Japan, Organization of Occupational Health and Safety https://researchmap.jp/yumi-umeda
Takeshi Izawa Laboratory of Veterinary Pathology, Osaka Metropolitan University Graduate School of Veterinary Science https://researchmap.jp/takeshiizawa/?lang=japanese
Kei Kazama Department of Veterinary Medicine, Azabu University, School of Veterinary Medicine https://researchmap.jp/kzm
Sachiko Arai Department of Veterinary Medicine, Azabu University, School of Veterinary Medicine https://researchmap.jp/read0127102
Junichi Kamiie Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University https://researchmap.jp/read0194202
Shinichiro Nakamura Laboratory of Laboratory Animal Science, School of Veterinary Medicine, Azabu University https://researchmap.jp/read0162294
Kazuki Hano Gifu University Institute for Advanced Study, Gifu University
Masaki Takasu Gifu University Institute for Advanced Study, Gifu University https://researchmap.jp/masaki-takasu
Akihiko Hirata Laboratory of Veterinary Pathology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University https://researchmap.jp/akatsuki
Susanne Rittinghausen Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)
Shotaro Yamano 独立行政法人労働者健康安全機構労働安全衛生総合研究所 https://researchmap.jp/jbrcyamano

DOI:

https://doi.org/10.51094/jxiv.854

キーワード:

Comparative anatomy、 Respiratory bronchiole、 Lobular structure、 Interlobular septum、 Lung

抄録

Rodents are widely used to study the toxicity of chemicals, but differences between species mean that results from rodents are not always directly transferrable to humans. The health of workers exposed to various chemicals and particulates in high doses or for long durations is at risk. The respiratory bronchioles and lobular structures are key sites for occupational lung diseases like pneumoconiosis, but these structures vary among animal species. Understanding these differences is crucial for studying the pathology of human occupational lung diseases. However, there is a lack of reviews focusing on these structures across different species. This review explores the lung anatomy of various mammals and its functional importance in disease to connect animal studies with human occupational lung diseases. Our results indicate that artiodactyls, especially small pig breeds and goats, are ideal for research because their respiratory bronchioles and lobular structures are similar to those of humans. This review aims to enhance the use of experimental animal data and improve our understanding of human occupational lung diseases, facilitating early detection, treatment, and prevention.

利益相反に関する開示

The authors have no competing interests to disclose.

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