Gradual decline of CD4⁺ T cells in cynomolgus macaques persistently infected with macaque-tropic HIV-1

Shofa, Maya; Ode, Hirotaka; Takiguchi, Mikoto; Koyanagi, Kana; Seki, Yohei; Washizaki, Ayaka; Akari, Hirofumi; Iwatani, Yasumasa; Fuke, Naoyuki; Urano, Emiko; Saito, Akatsuki; Yasutomi, Yasuhiro

doi:10.51094/jxiv.6160

##article.authors##

Shofa, Maya National Institutes of Biomedical Innovation, Health and Nutrition
Ode, Hirotaka NHO Nagoya Medical Center
Takiguchi, Mikoto University of Miyazaki
Koyanagi, Kana University of Miyazaki
Seki, Yohei Japan Institute for Health Security
Washizaki, Ayaka Arrowsmith Inc
Akari, Hirofumi Kyoto University
Iwatani, Yasumasa Hamamatsu University School of Medicine
Fuke, Naoyuki University of Miyazaki
Urano, Emiko National Institutes of Biomedical Innovation, Health and Nutrition
Saito, Akatsuki University of Miyazaki https://orcid.org/0000-0002-2792-4399
Yasutomi, Yasuhiro Hokkaido University https://orcid.org/0000-0001-8252-1448

DOI:

https://doi.org/10.51094/jxiv.6160

キーワード:

HIV-1、 cynomolgus macaque、 animal model、 macaque-tropic

抄録

Although macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) strains with high genomic similarity to HIV-1 have been engineered, their potential to cause acquired immunodeficiency syndrome (AIDS)-like symptoms in monkeys is essential for advancing HIV research. In this study, we revealed that long-term HIV-1mt infection in cynomolgus macaques causes progressive CD4⁺ T cell depletion, indicating increased pathogenicity. In addition, we identified adaptive amino acid substitutions in viral proteins that enhance replication fitness in macaque cells. These findings indicate that extended in vivo adaptation increases the pathogenic potential of HIV-1mt and provides novel perspectives on viral evolution and adaptation to the host.

利益相反に関する開示

The authors declare no competing financial interests

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