Regulation of macrophages in allergy by non-coding RNAs

Ishibashi, Osamu; Stefan Muljo; Zohirul Islam

doi:10.51094/jxiv.499

##article.authors##

Ishibashi, Osamu Laboratory of Biological Macromolecules, Graduate School of Agriculture, Osaka Metropolitan University https://orcid.org/0000-0003-4698-460X
Stefan Muljo Integrative Immunobiology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Zohirul Islam Integrative Immunobiology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)

DOI:

https://doi.org/10.51094/jxiv.499

キーワード:

noncoding RNA、 allergy、 macrophage、 macrophage polarization

抄録

Allergies are an immune reaction that is triggered by various substances known as allergens, which are represented by food and environmental substances such as plant pollen, fungal spores, and the feces and debris of mites and insects. Macrophages are immune cells with phagocytic abilities that process exogenous and endogenous antigens. The dysregulation of macrophage function leads to excessive inflammation, which includes allergic reactions. Thus, it is important to better understand how macrophages are regulated in the pathogenesis of allergies. Emerging evidence has highlighted the role of noncoding RNAs (ncRNAs) in macrophage polarization, which is involved in the pathogenesis of various immune-mediated diseases, including allergies. This review summarizes the current knowledge of ncRNA-regulated macrophage polarization that is related to allergies by focusing on three major ncRNA types: microRNAs, long ncRNAs, and circular RNAs. Furthermore, we discuss the potential therapeutic applications of targeting ncRNAs for allergy treatment.

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