この論文は以下の「著者最終稿」論文です。
書誌情報 : FEBS Letters, 597: 2672-2686 (2023)
DOI: https://doi.org/10.1002/1873-3468.14735Digital Object Identifier (DOI)
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Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities

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DOI:

https://doi.org/10.51094/jxiv.4192

キーワード:

ceramide、 ceramide phosphoethanolamine synthase、 D609、 diacylglycerol、 phosphatidylcholine-phospholipase C、 sphingomyelin synthase

抄録

Sphingomyelin (SM) synthase 1 (SMS1), which is involved in lipodystrophy, deafness, and thrombasthenia, generates diacylglycerol (DG) and SM using phosphatidylcholine (PC) and ceramide as substrates. Here, we found that SMS1 possesses DG-generating activities via hydrolysis of PC and phosphatidylethanolamine (PE) in the absence of ceramide and ceramide phosphoethanolamine synthase (CPES) activity. In the presence of the same concentration (4.7 mol%) of PC and ceramide, the amounts of DG produced by SMS and PC-phospholipase C (PLC) activities of SMS1 were approximately 65% and 35% of total DG production, respectively. PC-PLC activity showed substrate selectivity for saturated and/or monounsaturated fatty acid-containing PC species. A PC-PLC/SMS inhibitor, D609, inhibited only SMS activity. Mn2+ inhibited only PC-PLC activity. Intriguingly, DG attenuated SMS/CPES activities. Our study indicates that SMS1 is a unique enzyme with PC-PLC/PE-PLC/SMS/CPES activities.

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投稿日時: 2026-04-24 01:18:02 UTC

公開日時: 2026-06-04 01:33:57 UTC
研究分野
生物学・生命科学・基礎医学