Proteome Amino Acid Compositional Variation is Uniform Across 85 Species from the Three Domains of Life

Genshiro Esumi

doi:10.51094/jxiv.2928

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Genshiro Esumi Department of Pediatric Surgery, Hospital of the University of Occupational and Environmental Health https://orcid.org/0000-0003-0618-9943 https://researchmap.jp/esumig

DOI:

https://doi.org/10.51094/jxiv.2928

キーワード:

Proteome、 Amino acid composition、 Intra-specific variation、 Jensen-Shannon distance、 Mutual Constraint Model

抄録

Amino acid composition is a primary determinant of protein function; thus, the compositional variation within a proteome inherently defines its functional diversity. Quantifying this intra-proteomic variation and comparing it across species therefore addresses a fundamental question in genomic biology. Here, we evaluated this variation using the Jensen-Shannon (JS) distance across 85 species, comprising 81 species from the Reference Proteomes list and four additional species selected for their extreme genomic GC content. We calculated the JS distance between the amino acid composition of individual proteins and the corresponding proteome-wide average. Our results reveal that the distribution of this variation is remarkably uniform in both size and shape across all three domains of life. Given that a parallel analysis of gene nucleotide compositional variation showed no such uniformity, our findings suggest a universal selective pressure acting to govern amino acid compositional diversity within individual proteomes.

利益相反に関する開示

The author declare no conflicts of interest associated with this manuscript.

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