EVALUATION OF THE EFFECT OF PTYCHOPETALUM OLACOIDES (MUIRA PUAMA) EXTRACT ON ALUMINIUM CHLORIDE-INDUCED NEUROTOXICITY IN RATS.

Joshua Ajao; Akinsanmi Akinsehinwa; Olakunle Onaolapo; Adejoke Onaolapo

doi:10.51094/jxiv.1527

##article.authors##

Joshua Ajao Department of Pharmacology, Ladoke Akintola University of Technology
Akinsanmi Akinsehinwa Department of Anatomy , Ladoke Akintola University of Technology
Olakunle Onaolapo Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology
Adejoke Onaolapo Department of Anatomy, Ladoke Akintola University of Technology

DOI:

https://doi.org/10.51094/jxiv.1527

キーワード:

Aluminium Chloride、 Muira puama、 Neurotoxicity、 Neuroinflammation、 Neuroprotection

抄録

Muira puama is a plant renowned for its potent antioxidant and neuroprotective properties. The effects of ethanol extract of Muira puama on aluminium chloride-induced changes in rat behaviour and cerebral cortex histomorphology was examined in this study. Fifty male rats weighing 120-150 g each were divided into six groups: control (normal saline), Muira puama extract groups (25 mg/kg and 50 mg/kg), AlCl3 group (100 mg/kg), and AlCl3 combined with Muira puama extract groups (25 mg/kg and 50 mg/kg respectively). All treatments were administered orally for 21 days. Behaviours were assessed after the final dose of treatment. The result showed that the administration of AlCl3 was associated with decreased weight gain, behavioural alterations, and spatial working memory deficits. However, co-treatment with Muira puama was associated with increased food intake, reversal of weight loss, enhanced locomotion/self-grooming, and reduction of anxiety. Additionally, spatial working memory scores were significantly improved with Muira puama. Biochemical analysis showed reduced levels of malondialdehyde and tumour necrosis factor-alpha, and increased levels of interleukin 10 and total antioxidant capacity. Histological examination revealed neuronal preservation with Muira puama, suggesting protective effects on the cerebral cortex. These findings suggest that Muira puama extract has the ability to mitigate aluminium chloride-induced changes in rats. However, more studies would be needed to determine its suitability for use in humans.

利益相反に関する開示

The authors declare that they have no competing interests

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著者の経歴

Joshua Ajao、Department of Pharmacology, Ladoke Akintola University of Technology

Research Assistant , Department of Pharmacology

Akinsanmi Akinsehinwa、Department of Anatomy , Ladoke Akintola University of Technology

Research Assistant, Department of Anatomy

Olakunle Onaolapo、Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology

Reader, Department of Pharmacology and Therapeutics

Adejoke Onaolapo、Department of Anatomy, Ladoke Akintola University of Technology

Associate Professor, Department of Anatomy

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