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Association analysis between type 2 diabetes and the gut microbiota: a community-based cross-sectional study in Japan


  • Nagashima, Koji Department of Reseach & Development, TechnoSuruga Laboratory Co., Ltd.
  • Takayoshi Hisada Department of Reseach & Development, TechnoSuruga Laboratory Co., Ltd.
  • Jun Mochizuki Department of Research & Development, TechnoSuruga Laboratory Co., Ltd.
  • Tatsuya Mikami Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University
  • Yoshinori Tamada Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University
  • Shigeyuki Nakaji Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University




gut microbiota、 type 2 diabetes、 Lactobacillales、 community-based cross-sectional study


There are a few studies on the association between type 2 diabetes (T2D) and the gut microbiota but no community-based cross-sectional study. In the Iwaki Health Promotion Project (Hirosaki, Japan), we surveyed medical information and lifestyle and analyzed the gut microbiota using the terminal restriction fragment length polymorphism technique or next-generation sequencing. Based on these data, multivariable logistic regression analysis was performed with or without T2D as the dependent variable. Consequently, it was suggested that the Lactobacillales population in the gut microbiota was positively associated with T2D, consistent with the results of case-control studies.


The authors declare no competing interests.

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投稿日時: 2022-06-27 01:54:04 UTC

公開日時: 2022-06-28 09:35:04 UTC — 2023-08-14 06:19:38 UTCに更新



Some sentences (lines 142-158) were added . Refference (20) was added. The Word "healed" in line 55 of text and footnote of Table 1was revised to "ameliorated". A supplement file was added.